Sesquiterpene lactone trilobolide activates production of interferon-? and nitric oxide

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00350075" target="_blank" >RIV/61388963:_____/10:00350075 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/10:00350075

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Sesquiterpene lactone trilobolide activates production of interferon-? and nitric oxide

Original language description

Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclear cells secrete high amounts of IFN-?. The effect is associated with the stimulation of high output NO biosynthesis in rat cells. The effect does not seem to depend on enhanced intracellular calcium levels.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/GA305%2F07%2F0061" target="_blank" >GA305/07/0061: Immunopharmacological potential of endoplasmic Ca(2+)-ATPase (SERCA) inhibitors</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Fitoterapia

ISSN

0367-326X

e-ISSN

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Volume of the periodical

81

Issue of the periodical within the volume

8

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

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UT code for WoS article

000285281800044

EID of the result in the Scopus database

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