Sesquiterpene lactone trilobolide activates production of interferon-gamma and nitric oxide

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8675" target="_blank" >RIV/00216208:11110/10:8675 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/10:00300176
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sesquiterpene lactone trilobolide activates production of interferon-gamma and nitric oxide
Original language description
Trilobolide (TB), a sesquiterpene lactone isolated from Laser trilobum is an inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). We have found that upon the in vitro exposure to TB, rodent peritoneal cells and human peripheral blood mononuclearcells secrete high amounts of IFN-gamma. The effect is associated with the stimulation of high output NO biosynthesis in rat cells. The stimulatory potential of TB depends on the activation of MAP kinases p38 and ERK1/2, and transcription factor NF-kappa B. BAPTA-AM, a chelator of the intracellular calcium, remained without any effect on the secretion of IFN-gamma triggered by TB. These results demonstrate that TB is a potent immunostimulatory agent.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/GA305%2F07%2F0061" target="_blank" >GA305/07/0061: Immunopharmacological potential of endoplasmic Ca(2+)-ATPase (SERCA) inhibitors</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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