Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00376063" target="_blank" >RIV/61388963:_____/12:00376063 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bmc.2011.11.034" target="_blank" >http://dx.doi.org/10.1016/j.bmc.2011.11.034</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bmc.2011.11.034" target="_blank" >10.1016/j.bmc.2011.11.034</a>

Result language

angličtina

Original language name

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: Evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases

Original language description

Hypoxanthine-guanine-(xanthine) phosphoribosyltransferase catalyses the synthesis of the purine nucleoside monophosphates essential for DNA/RNA production in protozoan parasites. Acyclic nucleoside phosphonates have been found to inhibit Plasmodium falciparum. The study describes, how is the length of the aliphatic phosphonate linker depend on the enzymatic activity.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bioorganic & Medicinal Chemistry

ISSN

0968-0896

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

1076-1089

UT code for WoS article

000299496100059

EID of the result in the Scopus database

—