A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F12%3A00377463" target="_blank" >RIV/61388963:_____/12:00377463 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tet.2012.03.066" target="_blank" >http://dx.doi.org/10.1016/j.tet.2012.03.066</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tet.2012.03.066" target="_blank" >10.1016/j.tet.2012.03.066</a>

Result language
angličtina
Original language name
A novel type of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid
Original language description
An efficient synthesis of a novel class of acyclic nucleoside phosphonates derived from 2-(phosphonomethoxy)propanoic acid has been developed. The key step of the synthesis consists of the optimized oxidation of the 3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) analogues to the corresponding 2?-carboxy-PME (CPME) derivatives using the TEMPO/NaClO2/NaClO oxidizing system.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/VG20102015046" target="_blank" >VG20102015046: Targeted drug design for bioterrorism prevention. Development of effective inhibitors of the adenylate cyclase toxin of Bordetella pertusis and Bacillus anthracis.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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