Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00398512" target="_blank" >RIV/61388963:_____/13:00398512 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1002/med.21296" target="_blank" >http://dx.doi.org/10.1002/med.21296</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/med.21296" target="_blank" >10.1002/med.21296</a>

Result language
angličtina
Original language name
Medicinal Chemistry of Fluorinated Cyclic and Acyclic Nucleoside Phosphonates
Original language description
The fluorine atom plays an important role in medicinal chemistry because fluorine substitution has a strong impact on the physical, chemical, and biological properties of bioactive compounds. Such fluorine modifications have also been extensively studiedamong the pharmaceutically important class of nucleoside phosphonates, nucleotide analogues in which the phosphate group is replaced by the enzymatically and chemically stable phosphonate moiety. The fluorinated nucleoside phosphonates abound with antiviral, antiparasitic, and anticancer properties because they are able to act as inhibitors of important enzymes of nucleoside/nucleotide metabolism. In this paper, we review the biological properties of cyclic and acyclic nucleoside phosphonates modifiedby the attachment of one or more fluorine atoms to various parts of the molecule, namely to nucleobases, alkylphosphonate groups, cyclic or acyclic linkers, or to prodrug moieties.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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