Novel approach to the preparation of hemisuccinates of steroids bearing tertiary alcohol group

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00444168" target="_blank" >RIV/61388963:_____/15:00444168 - isvavai.cz</a>
Alternative codes found
RIV/60461373:22330/14:43897196
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2014.06.011" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2014.06.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.steroids.2014.06.011" target="_blank" >10.1016/j.steroids.2014.06.011</a>

Result language
angličtina
Original language name
Novel approach to the preparation of hemisuccinates of steroids bearing tertiary alcohol group
Original language description
17 beta-O-Hemisuccinates of typical representatives of Anabolic-Androgenic Steroids, 17 beta-hydroxy-17-methylandrostan-4-en-3-one, 17 beta-hydroxy-17-methyl-2-oxa-5 alpha-androstan-3-one, 17 beta-hydroxy-17-methyl-5 alpha-androstano-[3,2-c]pyrazole, were prepared. Several methods for the hemisuccinate preparation were tested. The indirect method using 1-ethyl-3-(dimethylaminopropyl)carbodiimide coupling reagent to form an ester bond of steroid with 2-(trimethylsilyl)ethyl hydrogen butanedioate was finally applied. Using the selectively removable protecting group, the desired hemisuccinates of steroids bearing tertiary alcohol group were obtained.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/VG20112015045" target="_blank" >VG20112015045: Rapid immunochemical tests for the detection of steroidal anabolics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)