Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00455314" target="_blank" >RIV/61388963:_____/15:00455314 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/15:00455314 RIV/00216208:11140/15:10316417
Result on the web
<a href="http://dx.doi.org/10.1016/j.fitote.2015.10.002" target="_blank" >http://dx.doi.org/10.1016/j.fitote.2015.10.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2015.10.002" target="_blank" >10.1016/j.fitote.2015.10.002</a>
Alternative languages
Result language
angličtina
Original language name
Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide
Original language description
Search for compounds with preserved immunobiological properties and decreased cytotoxicity led us to transform some structural features of trilobolide, particularly those related to their side chain functionality. For this reason, it was prepared over 20various deacylated, acyl modified, or relactonized derivatives of trilobolide. Their immunobiological effects were screened in vitro using the rat peritoneal cells primed with lipopolysaccharide. Secretion of interferon-gamma (IFN-gamma), interleukins (IL) IL-1beta, IL-6 and tumour necrosis factor-alpha (TNF-alpha) were determined by ELISA, and nitric oxide (NO) production by Griess reagent.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Fitoterapia
ISSN
0367-326X
e-ISSN
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Volume of the periodical
107
Issue of the periodical within the volume
Dec
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
90-99
UT code for WoS article
000367113000014
EID of the result in the Scopus database
2-s2.0-84946214153