Sugar modified pyrimido[4,5-b] indole nucleosides: synthesis and antiviral activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F17%3A00480133" target="_blank" >RIV/61388963:_____/17:00480133 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/17:10367342
Result on the web
<a href="http://pubs.rsc.org/en/content/articlehtml/2017/md/c7md00319f" target="_blank" >http://pubs.rsc.org/en/content/articlehtml/2017/md/c7md00319f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c7md00319f" target="_blank" >10.1039/c7md00319f</a>

Result language
angličtina
Original language name
Sugar modified pyrimido[4,5-b] indole nucleosides: synthesis and antiviral activity
Original language description
Three types of sugar modified pyrimido.4,5-b] indole nucleosides (2'-deoxy-2'-fluororibo-, 2'-deoxy-2'fluoroarabino- and arabinonucleosides) were synthesized by glycosylation of 4,6-dichloropyrimido.4,5b] indole followed by modification of sugar moiety and introduction of substituents into position 4 by cross-coupling reactions or nucleophilic substitutions. Some 2'-fluororibo- and 2'fluoroarabinonucleosides displayed interesting anti-HCV activities (IC50 = 1.6-20 mu M) and the latter compounds also some anti-dengue activities (IC50 = 10.8-40 mu M).
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10401 - Organic chemistry

Project
<a href="/en/project/GA16-00178S" target="_blank" >GA16-00178S: Novel nucleosides and nucleotides derived from hetero-fused 7-deazapurines</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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