Sugar modified pyrimidoij4,5-b]indole nucleosides: synthesis and antiviral activity

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F17%3A73584040" target="_blank" >RIV/61989592:15110/17:73584040 - isvavai.cz</a>

Result on the web

<a href="https://www.imtm.cz/sites/default/files/publication/impact/mcc_2017_1856pdf.pdf" target="_blank" >https://www.imtm.cz/sites/default/files/publication/impact/mcc_2017_1856pdf.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7md00319f" target="_blank" >10.1039/c7md00319f</a>

Result language

angličtina

Original language name

Sugar modified pyrimidoij4,5-b]indole nucleosides: synthesis and antiviral activity

Original language description

Three types of sugar modified pyrimidoij4,5-b]indole nucleosides (2′-deoxy-2′-fluororibo-, 2′-deoxy-2′-fluoroarabino- and arabinonucleosides) were synthesized by glycosylation of 4,6-dichloropyrimidoij4,5-b]indole followed by modification of sugar moiety and introduction of substituents into position 4 by cross-coupling reactions or nucleophilic substitutions. Some 2′-fluororibo- and 2′-fluoroarabinonucleosides displayed interesting anti-HCV activities (IC50 = 1.6–20 μM) and the latter compounds also some anti-dengue activities (IC50 = 10.8–40 μM).

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MedChemComm

ISSN

2040-2503

e-ISSN

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Volume of the periodical

2017

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

7

Pages from-to

1856-1862

UT code for WoS article

000411437800014

EID of the result in the Scopus database

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