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Determination of binding constants of human insulin complexes with serotonin, dopamine, arginine, and phenol by pressure assisted partial filling affinity capillary electrophoresis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F18%3A00498027" target="_blank" >RIV/61388963:_____/18:00498027 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf" target="_blank" >http://www.ce-ce.org/user_uploads/program/CECE%202018%20Proceedings_WOS.pdf</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Determination of binding constants of human insulin complexes with serotonin, dopamine, arginine, and phenol by pressure assisted partial filling affinity capillary electrophoresis

  • Original language description

    A new method, pressure assisted partial filling affinity capillary electrophoresis (PF-ACE), has been developed to study noncovalent interactions of the hexamer of human insulin (HI) with cationic ligands, such as phenolic neurotransmitters serotonin and dopamine, and amino acid arginine, or with anionic ligand phenol, in alkaline aqueous solutions. The apparent binding constants, Kb, of the HI-ligand complexes were determined from the dependence of the effective migration time changes of the above ligands on the variable zone lengths of HI dissolved in the background electrolyte and hydrodynamically introduced into the bare fused silica capillary close to the UV detector. The HI interactions with the above ligands were found to be moderately strong, with Kb values in the range 385-1314 L/mol.

  • Czech name

  • Czech description

Classification

  • Type

    D - Article in proceedings

  • CEP classification

  • OECD FORD branch

    10406 - Analytical chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Article name in the collection

    CECE 2018. 15th International Interdisciplinary Meeting on Bioanalysis

  • ISBN

    978-80-904959-5-1

  • ISSN

  • e-ISSN

  • Number of pages

    4

  • Pages from-to

    272-275

  • Publisher name

    Ústav analytické chemie AV ČR, v. v. i.

  • Place of publication

    Brno

  • Event location

    Brno

  • Event date

    Oct 15, 2018

  • Type of event by nationality

    WRD - Celosvětová akce

  • UT code for WoS article