The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F20%3A00533335" target="_blank" >RIV/61388963:_____/20:00533335 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1098/rsob.200137" target="_blank" >https://doi.org/10.1098/rsob.200137</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rsob.200137" target="_blank" >10.1098/rsob.200137</a>

Result language
angličtina
Original language name
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels
Original language description
Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However,the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not known. We showed that the disruption of zinc homeostasis in the model β-cells correlated with their impaired insulin and ZnT8 production. This indicates a need for in-depth fundamental research about the role of zinc in insulin production and storage.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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