Characterization of insulin crystalline form in isolated β-cell secretory granules

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00566032" target="_blank" >RIV/61388963:_____/22:00566032 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10455381
Result on the web
<a href="https://doi.org/10.1098/rsob.220322" target="_blank" >https://doi.org/10.1098/rsob.220322</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rsob.220322" target="_blank" >10.1098/rsob.220322</a>

Result language
angličtina
Original language name
Characterization of insulin crystalline form in isolated β-cell secretory granules
Original language description
Insulin is stored in vivo inside the pancreatic β-cell insulin secretory granules. However, the structural features of the storage forms of insulin in native preparations of secretory granules are unknown, because of their small size, fragile character and difficult handling. We isolated and investigated the secretory granules from MIN6 cells under near-native conditions, using cryo-electron microscopic (Cryo-EM) techniques. Our experimental data show that insulin can be pre-sent in pancreatic MIN6 cell granules in a microcrystalline form, probably consisting of 4Zn2+-hexamers of this hormone
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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