Potent Cyclic Tetrapeptide for Lead Detoxification

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00542235" target="_blank" >RIV/61388963:_____/21:00542235 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/anie.202103217" target="_blank" >https://doi.org/10.1002/anie.202103217</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/anie.202103217" target="_blank" >10.1002/anie.202103217</a>

Result language
angličtina
Original language name
Potent Cyclic Tetrapeptide for Lead Detoxification
Original language description
Lead (Pb) is a ubiquitous poisonous metal, affecting the health of vast populations worldwide. Medications to treat Pb poisoning suffer from various limitations and are often toxic owing to insufficient metal selectivity. Here, we report a cyclic tetrapeptide that selectively binds Pb and eradicates its toxic effect on the cellular level, with superior potency than state‐of‐the‐art drugs. The Pb‐peptide complex is remarkably strong and was characterized experimentally and computationally. Accompanied by the lack of toxicity and enhanced stability of this peptide, these qualities indicate its merit as a potential remedy for Pb poisoning.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/GA20-08772S" target="_blank" >GA20-08772S: Fundamental Principles of Protein Folding and Protein-Ligand Interactions Revealed by High-Level Quantum Chemical Calculations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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