Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00557865" target="_blank" >RIV/61388963:_____/22:00557865 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1002/cmdc.202200152" target="_blank" >https://doi.org/10.1002/cmdc.202200152</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/cmdc.202200152" target="_blank" >10.1002/cmdc.202200152</a>
Alternative languages
Result language
angličtina
Original language name
Cyclic Octapeptides Composed of Two Glutathione Units Outperform the Monomer in Lead Detoxification
Original language description
A rationally-designed scaffold of cyclic octapeptides composed of two units of the natural tripeptide glutathione (GSH) was optimized to strongly and selectively capture toxic lead ions (Pb(II)). Using state-of-the-art computational tools, a list of eleven plausible peptides was shortened to five analogs based on their calculated affinity to Pb(II) ions. We then synthesized and investigated them for their abilities to recover Pb-poisoned human cells. A clear pattern was observed from the in vitro detoxification results, indicating the importance of cavity size and polar moieties to enhance metal capturing. These, together with the apparent benefit of cyclizing the peptides, improved the detoxification of the two lead peptides by approximately two folds compared to GSH and the benchmark chelating agents against Pb poisoning. Moreover, the two peptides did not show any toxicity and, therefore, were thoroughly investigated to determine their potential as next-generation remedies for Pb poisoning.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA20-08772S" target="_blank" >GA20-08772S: Fundamental Principles of Protein Folding and Protein-Ligand Interactions Revealed by High-Level Quantum Chemical Calculations</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ChemMedChem
ISSN
1860-7179
e-ISSN
1860-7187
Volume of the periodical
17
Issue of the periodical within the volume
15
Country of publishing house
DE - GERMANY
Number of pages
7
Pages from-to
e202200152
UT code for WoS article
000799312900001
EID of the result in the Scopus database
2-s2.0-85130498319