Thiolation and Carboxylation of Glutathione Synergistically Enhance Its Lead-Detoxification Capabilities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F21%3A00550071" target="_blank" >RIV/61388963:_____/21:00550071 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1021/acs.inorgchem.1c03030" target="_blank" >https://doi.org/10.1021/acs.inorgchem.1c03030</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.inorgchem.1c03030" target="_blank" >10.1021/acs.inorgchem.1c03030</a>
Alternative languages
Result language
angličtina
Original language name
Thiolation and Carboxylation of Glutathione Synergistically Enhance Its Lead-Detoxification Capabilities
Original language description
The natural tripeptide glutathione (GSH) is a ubiquitous compound harboring various biological tasks, among them interacting with essential and toxic metal ions. Yet, although weakly binding the poisonous metal lead (Pb), GSH poorly detoxifies it. β-Mercaptoaspartic acid is a new-to-nature novel amino acid that was found to enhance the Pb-detoxification capability of a synthetic cyclic tetrapeptide. Aiming to explore the advantages of noncanonical amino acids (ncAAs) of this nature, we studied the detoxification capabilities of GSH and three analogue peptides, each of which contains at least one ncAA that harbors both free carboxylate and thiolate groups. A thorough investigation that includes in vitro detoxification and mechanistic evaluations, metal-binding affinity, metal selectivity, and computational studies shows that these ncAAs are highly beneficial in additively enhancing Pb binding and reveals the importance of both high affinity and metal selectivity in synergistically reducing Pb toxicity in cells. Hence, such ncAAs join the chemical toolbox against Pb poisoning and pollution, enabling peptides to strongly and selectively bind the toxic metal ion.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic Chemistry
ISSN
0020-1669
e-ISSN
1520-510X
Volume of the periodical
60
Issue of the periodical within the volume
24
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
18620-18624
UT code for WoS article
000753447800010
EID of the result in the Scopus database
2-s2.0-85120737256