Development of an Albumin-Polymer Bioconjugate via Covalent Conjugation and Supramolecular Interactions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00555120" target="_blank" >RIV/61388963:_____/22:00555120 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1021/acs.bioconjchem.1c00536" target="_blank" >https://doi.org/10.1021/acs.bioconjchem.1c00536</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.bioconjchem.1c00536" target="_blank" >10.1021/acs.bioconjchem.1c00536</a>
Alternative languages
Result language
angličtina
Original language name
Development of an Albumin-Polymer Bioconjugate via Covalent Conjugation and Supramolecular Interactions
Original language description
Preexisting serum albumin-polymer bioconjugates have been formed either through covalent conjugation or supramolecular interactions. However, the viability of producing a bioconjugate where both covalent conjugation and supramolecular interactions have been adopted is yet to be explored. In this work, the noncovalent interaction of two polymers bearing fatty acidbased end-functionalities were compared and the superior binder was carried forward for testing with serum albumin that possessed a polymer conjugated to its Cys34 residue. The studies demonstrated that an albumin-polymer bioconjugate equipped with polymers via both covalent and supramolecular interactions can be successfully achieved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bioconjugate Chemistry
ISSN
1043-1802
e-ISSN
1520-4812
Volume of the periodical
33
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
321-332
UT code for WoS article
000746547700001
EID of the result in the Scopus database
2-s2.0-85123610302