STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F22%3A00556396" target="_blank" >RIV/61388963:_____/22:00556396 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10451128
Result on the web
<a href="https://doi.org/10.1021/acsinfecdis.1c00554" target="_blank" >https://doi.org/10.1021/acsinfecdis.1c00554</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsinfecdis.1c00554" target="_blank" >10.1021/acsinfecdis.1c00554</a>

Result language
angličtina
Original language name
STING Agonist-Mediated Cytokine Secretion Is Accompanied by Monocyte Apoptosis
Original language description
The cGAS-STING (cyclic GMP-AMP synthase-stimulator of interferon genes) pathway plays a crucial role in inducing an antiviral and antitumor immune response. We studied the effects of synthetic STING agonists on several immune populations and related cytokine production. In comparison with the toll-like receptor 7 (TLR7) agonist, STING agonists induced secretion of a broader proinflammatory cytokine spectrum. Unlike the TLR7 agonist, the structurally diverse STING agonists partially depleted B and NK cells and completely depleted CD14+ monocytes via induction of apoptosis. The TANK-binding kinase 1 inhibitor efficiently prevented interferon alpha (IFN alpha) secretion and cell depletion, suggesting their possible dependence on the cGAS-STING pathway activation. Finally, IFN alpha, tumor necrosis factor alpha, interleukin 6, and interleukin 1 beta secretion and CD14+ monocyte apoptosis were primary responses to STING agonists, whereas IFN gamma was secreted secondarily. These findings bring new insights into the cGAS-STING pathway immunomodulation that is of future therapeutic importance.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
<a href="/en/project/EF16_019%2F0000729" target="_blank" >EF16_019/0000729: Chemical biology for drugging undruggable targets</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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