Synthesis and Biological Profiling of Benzofuro-Fused 7-Deazapurine Nucleosides

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F23%3A00577107" target="_blank" >RIV/61388963:_____/23:00577107 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10474278 RIV/61989592:15110/23:73621060 RIV/00098892:_____/23:10158527
Result on the web
<a href="https://doi.org/10.1002/ejoc.202300723" target="_blank" >https://doi.org/10.1002/ejoc.202300723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ejoc.202300723" target="_blank" >10.1002/ejoc.202300723</a>

Result language
angličtina
Original language name
Synthesis and Biological Profiling of Benzofuro-Fused 7-Deazapurine Nucleosides
Original language description
A series of benzofuro-fused 7-deazapurine (6H-furo[2,3-e]pyrimido[4,5-b]indole) 2’-deoxyribo- and ribonucleosides was designed and synthesized. The synthesis of key compound 10-chloro-6H-furo[2,3-e]pyrimido[4,5-b]indole was based on the Negishi cross-coupling of iodobenzofurane with zincated 4,6-dichloropyrimidine followed by azidation and photochemical cyclization. Glycosylation of the heterocycle with either Hoffer's chlorodeoxyribose or protected ribose followed by cross-coupling or substitution reactions at position 10 gave the desired two sets of final nucleosides that showed moderate to weak cytostatic activity and interesting fluorescence properties.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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