Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F25%3A00637915" target="_blank" >RIV/61388963:_____/25:00637915 - isvavai.cz</a>

Alternative codes found

RIV/68378271:_____/25:00637915 RIV/61388971:_____/25:00637915 RIV/61389013:_____/25:00637915 RIV/00216208:11110/25:10500126 and 2 more

Result on the web

<a href="https://pubs.acs.org/doi/10.1021/acsanm.5c03013" target="_blank" >https://pubs.acs.org/doi/10.1021/acsanm.5c03013</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsanm.5c03013" target="_blank" >10.1021/acsanm.5c03013</a>

Result language

angličtina

Original language name

Nickel Ferrite Nanoparticles for In Vivo Multimodal Magnetic Resonance and Magnetic Particle Imaging

Original language description

Magnetic nanoparticles have been at the center of biomedical research for decades, primarily for their applications in magnetic resonance imaging (MRI) and magnetic particle imaging (MPI). Superparamagnetic particles, typically based on iron oxide crystals, are effective in both modalities, although each requires distinct magnetic properties for optimal performance. We investigated the performance of nanoparticles based on a nickel-substituted ferrite core and compared them to standard maghemite iron oxide nanoparticles. We synthesized gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles and coated them with a statistical copolymer poly(N,N-dimethylacrylamide-co-acrylic acid). In vitro testing included X-ray diffraction (XRD), Mossbauer spectroscopy, magnetometry, magnetic resonance relaxometry, magnetic particle spectroscopy, and imaging. In vivo testing involved monitoring of nanoparticle biodistribution using MPI and MRI after intracardial application in a murine model. Mossbauer spectra suggest that the Ni-substituted nanoparticles consist of a stoichiometric NiFe2O4 ferrite and a poorly crystalline antiferromagnetic iron(III) oxide-hydroxide phase. Amorphous-like impurities in Ni x Fe2-x O3 nanoparticles were probably responsible for lower saturation magnetization than that of gamma-Fe2O3 nanoparticles, as was proved by magnetometry, which led to lower r 2 relaxivity. However, MPI revealed a higher signal in the spectrum and superior imaging performance of Ni x Fe2-x O3 compared to gamma-Fe2O3 particles, likely due to shorter Neel and Brownian relaxation times. Both types of nanoparticles showed similar performance in bimodal MRI/MPI imaging in vivo. They were detected in the liver immediately after application and appeared in the spleen within 24 h. Long-term localization in the lymph nodes was also observed. Substituting an iron with a nickel ion in the core altered the magnetic properties, leading to lower saturation magnetization and an increased signal in the magnetic particle spectra, which enhanced their performance in MPI. This study demonstrates that gamma-Fe2O3 and Ni x Fe2-x O3 nanoparticles are both suitable for combined MRI/MPI imaging, magnetic particle imaging provides a highly specific signal for anatomical magnetic resonance images.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10406 - Analytical chemistry

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ACS Applied Nano Materials

ISSN

2574-0970

e-ISSN

2574-0970

Volume of the periodical

8

Issue of the periodical within the volume

29

Country of publishing house

US - UNITED STATES

Number of pages

15

Pages from-to

14867-14881

UT code for WoS article

001530667300001

EID of the result in the Scopus database

2-s2.0-105014174905