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Rabbit Liver Microsomal System: Study of Interaction with Two Model N-Nitrosamines and Their Metabolism

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F04%3A00022749" target="_blank" >RIV/61388971:_____/04:00022749 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/04:8378

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Rabbit Liver Microsomal System: Study of Interaction with Two Model N-Nitrosamines and Their Metabolism

  • Original language description

    Rabbit liver microsomes of control or animals induced either by ethanol or phenobarbital were incubated with N-nitrosodimethylamine or N-nitrosomethylaniline and interaction and metabolism were studied. Base on both method the CYP 2E1, the major inducedform by ethanol, were validate as the enzyme mainly responsible for activation of both these carcinogenes.

  • Czech name

    Králičí mikrosomální systém: interakce a metabolismus dvou modelových N-nitrosaminů

  • Czech description

    Jaterní mikrosomy králíka z kontrolních, a etanolem a fenobarbitalem premedikovaných jedinců byly inkubovány s N-nitrosodimethylaminem nebo N-nitrosomethylanilinem a byla studována jejich interakce a metabolismus. Na základě výsledků obou metod byl určenCYP 2E1, hlavní etanolem indukovaná forma, jako enzym zodpovědný za aktivaci obou studovaných karcinogenů.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2004

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    General Physiology and Biophysics

  • ISSN

    0231-5882

  • e-ISSN

  • Volume of the periodical

    23

  • Issue of the periodical within the volume

    -

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    11

  • Pages from-to

    423-433

  • UT code for WoS article

  • EID of the result in the Scopus database