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Efficient Ex Vivo Stimulation of Mycobacterium tuberculosis-Specific T Cells by Genetically Detoxified Bordetella pertussis Adenylate Cyclase Antigen Toxodids

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F05%3A00021773" target="_blank" >RIV/61388971:_____/05:00021773 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Efficient Ex Vivo Stimulation of Mycobacterium tuberculosis-Specific T Cells by Genetically Detoxified Bordetella pertussis Adenylate Cyclase Antigen Toxodids

  • Original language description

    Mycobacterium tuberculosis is a significant threat to global health. Mycobacterium bovis BCG vaccine provides only partial protection, and the skin test reagent used to aid diagnosis of both active and latent tuberculosis, purified protein derivative (PPD), lacks specificity and sensitivity. The use of genetically detoxified Bordetella pertussis adenylate cyclase toxin (CyaA) as a delivery system for two immunodominant proteins of M. tuberculosis that are of greater specificity than PPD, early-secretedantigenic target 6-kDa protein (ESAT-6) and culture filtrate protein 10 (CFP-10), was therefore investigated. CyaA toxoids incorporating these antigens were able to restimulate T cells from more than 91% tuberculosis patients and healthy sensitized donors.

  • Czech name

    Účinná Ex vivo stimulace T buněk specifických pro Mycobacterium tuberculosis pomocí geneticky detoxifikovaného adenylát-cyclasového toxoidu z Bordetella pertussis

  • Czech description

    Práce ukazuje, že geneticky upravený ? detoxifikovaný ? adeylát-cyklasový toxoid se zabudovanými antigeny ESAT-6 a CFP-10, původem z Mycobacterium tuberculosis, lze použít k dopravě těchto antigenů do prezentujících buněk v lidské krvi a tím navodit specifickou prezentaci antigenů a re-stimulaci přítomných T-buněčných klonů v krvi infikovaných lidí in vitro. To má skýtá dalekosáhlé možnosti pro vylepšení stávajících diagnostických metod a detekci latentní infekce bakterií Mycobacterium tuberculosis, původcem tuberkulosy

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EE - Microbiology, virology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2005

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Infection and Immunity

  • ISSN

    0019-9567

  • e-ISSN

  • Volume of the periodical

    73

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    2991-2998

  • UT code for WoS article

  • EID of the result in the Scopus database