Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F06%3A00040342" target="_blank" >RIV/61388971:_____/06:00040342 - isvavai.cz</a>

Alternative codes found

RIV/00023736:_____/06:00006672

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Prime/boost immunotherapy of HPV16-induced tumors with E7 protein delivered by Bordetella adenylate cyclase and modified vaccinia virus Ankara

Original language description

We show here that vaccination with a genetically detoxified CyaA336/E7 protein, carrying the full-length oncoprotein E7 of the human papilloma virus 16 inserted at position 336 of the cell-invasive AC domain of CyaA, induces an E7-specific CD8+ T-cell immune response and confers on mice protective, as well as therapeutic, immunity against challenge with TC-1 tumor cells expressing the oncoprotein E7. The therapeutic efficacy of priming with the CyaA336/E7 vaccine could further be enhanced by a heterologous booster immunization with a highly attenuated modified vaccinia virus Ankara (MVA) expressing the E7 protein fused to the lysosome-associated membrane protein LAMP1. These results establish the potential of CyaA as a new antigen delivery tool for prime/boost immunotherapy of tumors

Czech name

Prime/boost imunoterapie nádorů vyvolaných HPV16 proteinem E7 dopravovaným adenylát-cyklázou z Bordetella a modifikovaným virem vakcínie Ankara

Czech description

Geneticky detoxifikovaný protein CyaA336/E7 dopravující antigen E7 lidských papiloma virů HPV16 indukuje dostatečnou buněčně zprostředkovanou specifickou imunitní odpověď proti nádorům vyvolaným virem HPV16. Kombinace imunizace CyaA336/E7 a imunizace pomocí viru vakcinie nesoucímu protein E7 vede k imunoterapii nádorů vyvolaných HPV16 u myší

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer Immunology and Immunotherapy

ISSN

0340-7004

e-ISSN

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Volume of the periodical

55

Issue of the periodical within the volume

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Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

39-46

UT code for WoS article

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EID of the result in the Scopus database

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