Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F07%3A00084887" target="_blank" >RIV/61388971:_____/07:00084887 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Eukaryotic-Type Serine/Threonine Protein Kinase StkP Is a Global Regulator of Gene Expression in Streptococcus pneumoniae

Original language description

Signal transduction pathways in both prokaryotes and eukaryotes utilize protein phosphorylation as a key regulatory mechanism. Recent studies have proven that eukaryotic-type serine/threonine protein kinases (Hanks-type) are widespread in many bacteria,although little is known regarding the cellular processes they control. In this study, we have attempted to establish the role of a single eukaryotic-type protein kinase, StkP of Streptococus pneumoniae, in bacterial survival. Our results indicate that expression of StkP is important for the resistance of S. pneumoniae to various stress conditions. To investigate the impact of StkP on this phenotype, we compared the whole-genome expression profiles of the wild type and ?stkP mutant strains by microarraytechnology. This analysis revealed that StkP positively controls transcription of a set of genes encoding functions involved in cell wall metabolism, pyrimidine biosynthesis, DNA repair, iron uptake and oxidative stress response

Czech name

Serin-threoninová proteinkinasa StkP jako globální regulátor genové exprese Streptococcus pneumoniae

Czech description

Tato studie se zabývá analýzou funkce proteinkinasy eukaryotního typu StkP u Streptococcus pneumoniae. Bylo zjištěno, že exprese StkP je důležitá pro rezistenci S. pneumoniae k různým druhům stresů. Dále byly porovnány expresní profily kmenů divokého typu a mutanta ?stkP a bylo prokázáno, že StkP kontroluje expresi genů kódujících proteiny rozličné funkce

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Bacteriology

ISSN

0021-9193

e-ISSN

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Volume of the periodical

189

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

4168-4179

UT code for WoS article

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EID of the result in the Scopus database

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