New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F08%3A00306763" target="_blank" >RIV/61388971:_____/08:00306763 - isvavai.cz</a>
Alternative codes found
RIV/61389013:_____/08:00306763 RIV/61388971:_____/08:00359072 RIV/61389013:_____/08:00359072 RIV/00064203:_____/08:6929
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting
Original language description
Various conjugates of anticancer drug doxorubicin covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesised. Structure of the conjugates differed inthe type and the content of hydrophobic substituent (dodecyl, oleic acid and cholesterol moieties) introduced into the polymer structure.
Czech name
Nové polymerní nosiče na bázi HPMA kopolymerů s kovalentně vázanými hydrofobními substituenty pro směrování do pevných nádorů
Czech description
Syntetizovány byly konjugáty protinádorového léčiva doxorubicinu, kovalentně vázaného hydrolyticky degradovatelnou hydrazonovou vazbou k polymernímu nosiče na bázi kopolymerů N-(2-hydroxypropyl)methakylamidu (HPMA). Struktura konjugátů se lišila v typu aobsahu hydrofobního substituentu (dodecyl, derivát kyseliny olejové či cholesterolu) zavedených do polymerní struktury.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CD - Macromolecular chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Controlled Release
ISSN
0168-3659
e-ISSN
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Volume of the periodical
127
Issue of the periodical within the volume
2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
10
Pages from-to
121-130
UT code for WoS article
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EID of the result in the Scopus database
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