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New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F08%3A00306763" target="_blank" >RIV/61388971:_____/08:00306763 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389013:_____/08:00306763 RIV/61388971:_____/08:00359072 RIV/61389013:_____/08:00359072 RIV/00064203:_____/08:6929

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting

  • Original language description

    Various conjugates of anticancer drug doxorubicin covalently bound by the hydrolytically degradable hydrazone bond to the drug carrier based on N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers were synthesised. Structure of the conjugates differed inthe type and the content of hydrophobic substituent (dodecyl, oleic acid and cholesterol moieties) introduced into the polymer structure.

  • Czech name

    Nové polymerní nosiče na bázi HPMA kopolymerů s kovalentně vázanými hydrofobními substituenty pro směrování do pevných nádorů

  • Czech description

    Syntetizovány byly konjugáty protinádorového léčiva doxorubicinu, kovalentně vázaného hydrolyticky degradovatelnou hydrazonovou vazbou k polymernímu nosiče na bázi kopolymerů N-(2-hydroxypropyl)methakylamidu (HPMA). Struktura konjugátů se lišila v typu aobsahu hydrofobního substituentu (dodecyl, derivát kyseliny olejové či cholesterolu) zavedených do polymerní struktury.

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CD - Macromolecular chemistry

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2008

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Controlled Release

  • ISSN

    0168-3659

  • e-ISSN

  • Volume of the periodical

    127

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    10

  • Pages from-to

    121-130

  • UT code for WoS article

  • EID of the result in the Scopus database