Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00330776" target="_blank" >RIV/61388971:_____/09:00330776 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/09:00330776
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Targed neural stem cell differentiation and related cell based therapy in spinal cord injury
Original language description
Transplantation of stem cells represents a unique approach to treat spinal trauma. To follow in vivo traumatic changes, the signalling proteins were studied in the rat spinal cord transsection. 80th motoneurons and sensory neurons were subjected to analysis. Computer modeling of protein changes indicates that downregulated proteins belong to oxidative stress response as well as cellular fate and organisation. Increase of proteins involved in genome maintenance was observed in ventral horns. Only marginal changes were found in the dorsal root ganglia. To characterise mechanisms governing differentiation we combined the porcine neural stem cells in vitro differentiation and complementary proteomic analyses. The stem cells exhibited high levels of GRK2 and several members of FAS pathway. Typical for differentiated neural cells were enhanced integrin, PDGF and MAP kinase signalling and heme-oxygenase 2. Characterisation of changes related to cell differentiation helps to define suitab
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0538" target="_blank" >1M0538: Center for Cell Therapy and Tissue Repair</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
3rd Central and Eastern Proteomics Conference, 2009
ISBN
978-963-9319-99-8
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
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Publisher name
Hungarian proteomic society
Place of publication
Budapest
Event location
Budapešť
Event date
Oct 6, 2009
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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