In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F09%3A00338289" target="_blank" >RIV/61388971:_____/09:00338289 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/09:00338289
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
In-depth study of the human follicular fluid for a diagnostic / prognostic marker of ovarian hyperstimulation syndrome
Original language description
Ovarian hyperstimulation syndrome (OHSS) is a serious complication of in vitro fertilisation therapy using hormonal stimulation of ovaries. Current diagnosis is not sufficient and could be significantly improved if a protein biomarker(s) could be identified in patient follicular fluid (HFF). In search for new potential diagnostic and prognostic biomarker(s) of OHSS we have used a combination of immunoaffinity depletion, 2-D LC and 2-DE to obtain 2D protein profiles of HFF from OHSS positive and OHSS negative women. The protein maps were evaluated using software tools and protein spots or bands significantly increased or decreased in HFF of OHSS positive and OHSS negative women were identified using MS. In total, we identified 20 proteins and 3 of themwere shared between two different 2D technologies. Most of the identified proteins belong to different functional groups including the complement cascade, transport, blood coagulation, acute phase response and inflammation.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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