Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10977" target="_blank" >RIV/00216208:11110/11:10977 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/11:00368287 RIV/67985904:_____/11:00368287 RIV/00064165:_____/11:10977
Result on the web
<a href="http://dx.doi.org/10.1093/molehr/gar047" target="_blank" >http://dx.doi.org/10.1093/molehr/gar047</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Development of ovarian hyperstimulation syndrome: interrogation of key proteins and biological processes in human follicular fluid of women undergoing in vitro fertilization
Original language description
Ovarian hyperstimulation syndrome (OHSS) is an iatrogenic complication and potentially life-threatening condition resulting from excessive ovarian stimulation during assisted reproductive technologies. Our aim was to identify candidate proteins in follicular fluid (FF) using various proteomic approaches which may help to identify patients at risk of OHSS. We analysed the proteome alterations in FF from patients suffering from severe forms of OHSS (OHSS+) compared with a control group of women without orwith only mild signs of OHSS (OHSS-). The 12 abundant proteins of FF were removed using an immunoaffinity system. Pools of remaining depleted proteins were applied to the two-dimensional (2D) electrophoresis and 2D liquid chromatography and proteins indifferentially expressed protein spots/fractions were identified by mass spectrometry. Among a total of 19 candidate proteins differentially expressed (P < 0.05) between OHSS+ and OHSS- FF samples, three proteins, namely ceruloplasmin, co
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FK - Gynaecology and obstetrics
OECD FORD branch
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Project
<a href="/en/project/NS9781" target="_blank" >NS9781: Biomarkers of ovarian hyperstimulation syndrome (OHSS) in follicular fluid and plasma/serum of IVF patients - a proteomic study.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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