Interaction of late apoptotic and necrotic cells with vitronectin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F11%3A00365171" target="_blank" >RIV/61388971:_____/11:00365171 - isvavai.cz</a>
Alternative codes found
RIV/68378050:_____/11:00365171 RIV/00023736:_____/11:00009193
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0019243" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0019243</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0019243" target="_blank" >10.1371/journal.pone.0019243</a>
Alternative languages
Result language
angličtina
Original language name
Interaction of late apoptotic and necrotic cells with vitronectin
Original language description
Vitronectin (Vn) is an abundant plasma glycoprotein identified also as a part of extracellular matrix. Vn is substantially enriched at sites of injured, fibrosing, inflamed, and tumor tissues where it is believed to be involved in wound healing and tissue remodeling. Little is known about the mechanism of Vn localization into the damaged tissues. 2E12 antibody has been described to bind a subset of late apoptotic cells. The antigen recognized by 2E12 antibody was identified as Vn. Vn binds to the late apoptotic and necrotic cells in cell cultures in vitro as well as in murine thymus and spleen in vivo. Confocal microscopy revealed that Vn binds to an intracellular cytoplasmic structure after the membrane rupture. Vitronectin could serve as a marker ofmembrane disruption in necrosis and apoptosis for flow cytometry analysis. Vn binding to dead cells may represent one of the mechanisms of Vn incorporation into the injured tissues.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/1M0506" target="_blank" >1M0506: Center of Molecular and Cellular Immunology</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
"e19243"
UT code for WoS article
000290224800019
EID of the result in the Scopus database
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