Integrative Binding Sites within Intracellular Termini of TRPV1 Receptor

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F12%3A00386553" target="_blank" >RIV/61388971:_____/12:00386553 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00386553
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0048437" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0048437</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0048437" target="_blank" >10.1371/journal.pone.0048437</a>

Result language
angličtina
Original language name
Integrative Binding Sites within Intracellular Termini of TRPV1 Receptor
Original language description
The transient receptor potential channel TRPV1 is a nonselective cation channel that integrates wide range of painful stimuli. It has been shown that its activity could be modulated by intracellular ligands PIP2 or calmodulin (CaM). In our study we usedfluorescence anisotropy and surface plasmon resonance measurements to characterize the PIP2 binding to TRPV1. We characterized one PIP2 binding site in TRPV1 N-terminal region (F189-V221), and two independent PIP2 binding sites in C-terminus (K688-K718 and L777-S820)
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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