Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F14%3A00435341" target="_blank" >RIV/61388971:_____/14:00435341 - isvavai.cz</a>

Alternative codes found

RIV/61389005:_____/14:00435341 RIV/61388963:_____/14:00435341 RIV/68407700:21460/14:00227809

Result on the web

<a href="http://dx.doi.org/10.1039/c4nr02570a" target="_blank" >http://dx.doi.org/10.1039/c4nr02570a</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4nr02570a" target="_blank" >10.1039/c4nr02570a</a>

Result language

angličtina

Original language name

Comprehensive interrogation of the cellular response to fluorescent, detonation and functionalized nanodiamonds

Original language description

Nanodiamonds (NDs) are versatile nanoparticles that are currently being investigated for a variety of applications in drug delivery, biomedical imaging and nanoscale sensing. Although initial studies indicate that these small gems are biocompatible, there is a great deal of variability in synthesis methods and surface functionalization that has yet to be evaluated. Here we present a comprehensive analysis of the cellular compatibility of an array of nanodiamond subtypes and surface functionalization strategies. These results demonstrate that NDs are well tolerated by multiple cell types at both functional and gene expression levels. In addition, ND-mediated delivery of daunorubicin is less toxic to multiple cell types than treatment with daunorubicin alone, thus demonstrating the ability of the ND agent to improve drug tolerance and decrease therapeutic toxicity. Overall, the results here indicate that ND biocompatibility serves as a promising foundation for continued preclinical inves

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/LM2011019" target="_blank" >LM2011019: CANAM (Center of Accelerators and Nuclear Analytical Methods)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanoscale

ISSN

2040-3364

e-ISSN

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Volume of the periodical

6

Issue of the periodical within the volume

20

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

11712-11721

UT code for WoS article

000343000800018

EID of the result in the Scopus database

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