The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F15%3A00456148" target="_blank" >RIV/61388971:_____/15:00456148 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.dci.2015.02.014" target="_blank" >http://dx.doi.org/10.1016/j.dci.2015.02.014</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dci.2015.02.014" target="_blank" >10.1016/j.dci.2015.02.014</a>

Result language
angličtina
Original language name
The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets
Original language description
Porcine ileum is populated with a high proportion of B cells but previous studies have shown that they are not developed there. While B cells prevail in the ileum even in germ-free animals, microbial colonization is a major factor that causes even a greater prevalence of B cells in the ileum and further differential representation of lymphoid cells throughout small intestine. Analysis of lymphoid subpopulations showed that the effector cells appear only after colonization. These include class-switched IgM(+)IgA(+) B cells, primed CD2(-)CD21(+) B cells, antibody-producing/memory CD2(+)CD21(-) B cells, and effector/memory CD4(+)CD8(+) alpha beta Th cells. While colonization resulted in a uniform distribution of effector cells throughout the gut, it caused a decrease in the frequency of cytotoxic alpha beta and CD2(+)CD8(+) gamma delta T cells. These results suggest that the ileum is a site where naive B cells expand presumably to increase antibody repertoire but the entire small intestin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Project
<a href="/en/project/GAP502%2F12%2F0110" target="_blank" >GAP502/12/0110: The role of gammadelta T cells in immunization of porcine naive immune system</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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