Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00462551" target="_blank" >RIV/61388971:_____/16:00462551 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/16:00462551 RIV/61989592:15110/16:33158999
Result on the web
<a href="http://dx.doi.org/10.1021/acs.jnatprod.5b00905" target="_blank" >http://dx.doi.org/10.1021/acs.jnatprod.5b00905</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jnatprod.5b00905" target="_blank" >10.1021/acs.jnatprod.5b00905</a>
Alternative languages
Result language
angličtina
Original language name
Effects of 2,3-Dehydrosilybin and Its Galloyl Ester and Methyl Ether Derivatives on Human Umbilical Vein Endothelial Cells
Original language description
The effects in vitro of 2,3-dehydrosilybin and several galloyl esters and methyl ethers on the viability, proliferation, and migration of human umbilical vein endothelial cells (HUVECs) were evaluated. The monogalloyl esters were synthesized by a chemoselective esterification method or by Steglich esterification of suitably protected 2,3-dehydrosilybin (1) with protected gallic acid. 2,3-Dehydrosilybin (1) displayed more potent cytotoxic, anti proliferative, and antimigratory activities (IC50 12.0, 5.4, and 12.2 mu M, respectively) than silybin. The methylated derivatives were less active, with the least potent being 3,7-di-O-methyl-2,3-dehydrosilybin (6). On the other hand, galloylation at C-7 OH and C-23 OH markedly increased the cytotoxicity and the effects on the proliferation and migration of HUVECs.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Natural Products
ISSN
0163-3864
e-ISSN
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Volume of the periodical
79
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
812-820
UT code for WoS article
000374915800019
EID of the result in the Scopus database
2-s2.0-84966937531