Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009502" target="_blank" >RIV/61989592:15110/09:00009502 - isvavai.cz</a>

Alternative codes found

RIV/67985823:_____/09:00328277 RIV/61388971:_____/09:00328277

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups.

Original language description

The flavonolignans silybin (1) and 2,3-dehydrosilybin (2) are important natural compounds with multiple biological activities operating at various cell levels. Many of these effects are connected with their radical-scavenging activities. The molecular mechanisms of the antioxidant activity of these compounds and even the functional groups responsible for this activity are not yet well known. Their mechanism can be inferred from the structures of the dimeric products obtained from radical-mediated reactions of selectively methylated derivatives of 1 and 2. The radical oxidation of 1 methylated at 7-OH and 2 methylated at both 3-OH and 7-OH yields C-C and C-O dimers that enable the molecular mechanism of their E-ring interaction with radicals to be elucidated and shows the importance of the 20-OH group in this respect. The pivotal role of the 3-OH group in the radical-scavenging activity of 2 was confirmed through the formation of another type of dimer from its selectively methylated der

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Free Radical Biology & Medicine

ISSN

0891-5849

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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