Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00463320" target="_blank" >RIV/61388971:_____/16:00463320 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1126/science.aad8588" target="_blank" >http://dx.doi.org/10.1126/science.aad8588</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.aad8588" target="_blank" >10.1126/science.aad8588</a>

Result language
angličtina
Original language name
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition
Original language description
In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growt
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
—

Project
<a href="/en/project/GAP303%2F12%2F0535" target="_blank" >GAP303/12/0535: Mechanisms of the anti-inflammatory effects of commensal and probiotic bacteria and their role in metabolism and drug pharmacokinetics</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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