Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F16%3A00463864" target="_blank" >RIV/61388971:_____/16:00463864 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2016/3047574" target="_blank" >http://dx.doi.org/10.1155/2016/3047574</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2016/3047574" target="_blank" >10.1155/2016/3047574</a>
Alternative languages
Result language
angličtina
Original language name
Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring
Original language description
Studies have documented that the pathogenesis of autoimmune diabetes is influenced by the intake of gluten. Aims. To investigate the importance of gluten exposure during pregnancy and the subsequent development of autoimmune diabetes in offspring. Methods. Nonobese diabetic mice were divided into 7 groups to receive combinations of gluten-free and standard diet before, during, or after pregnancy. Diabetes incidence in offspring was followed in each group (n = 16-27) for 310 days. Insulitis score and intestinal expression of T-cell transcription factors (RT-QPCR) were evaluated in animals from the different diet groups. Results. If mothers were fed a gluten-free diet only during pregnancy, the development of autoimmune diabetes in offspring was almost completely prevented with an incidence reduction from 62.5% in gluten-consuming mice to 8.3% (P < 0.0001) in the gluten-free group.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-24487S" target="_blank" >GA15-24487S: Immune mechanisms of gliadin/gluten in pathogenesis and prevention of type 1 diabetes: two immuno-preventive strategies for translation to humans.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Diabetes Research
ISSN
2314-6745
e-ISSN
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Volume of the periodical
2016
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000382686400001
EID of the result in the Scopus database
2-s2.0-84985918188