Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504271" target="_blank" >RIV/61388971:_____/19:00504271 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2073-4409/8/3/259" target="_blank" >https://www.mdpi.com/2073-4409/8/3/259</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cells8030259" target="_blank" >10.3390/cells8030259</a>

Result language

angličtina

Original language name

Microtubular and Nuclear Functions of gamma-Tubulin: Are They LINCed?

Original language description

gamma-Tubulin is a conserved member of the tubulin superfamily with a function in microtubule nucleation. Proteins of gamma-tubulin complexes serve as nucleation templates as well as a majority of other proteins contributing to centrosomal and non-centrosomal nucleation, conserved across eukaryotes. There is a growing amount of evidence of gamma-tubulin functions besides microtubule nucleation in transcription, DNA damage response, chromatin remodeling, and on its interactions with tumor suppressors. However, the molecular mechanisms are not well understood. Furthermore, interactions with lamin and SUN proteins of the LINC complex suggest the role of gamma-tubulin in the coupling of nuclear organization with cytoskeletons. gamma-Tubulin that belongs to the clade of eukaryotic tubulins shows characteristics of both prokaryotic and eukaryotic tubulins. Both human and plant gamma-tubulins preserve the ability of prokaryotic tubulins to assemble filaments and higher-order fibrillar networks. gamma-Tubulin filaments, with bundling and aggregating capacity, are suggested to perform complex scaffolding and sequestration functions. In this review, we discuss a plethora of gamma-tubulin molecular interactions and cellular functions, as well as recent advances in understanding the molecular mechanisms behind them.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

<a href="/en/project/GA15-11657S" target="_blank" >GA15-11657S: Role of gamma- tubulin in the coordination of microtubule nucleation and cell division with the DNA damage response pathway in plants</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cells

ISSN

2073-4409

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

17

Pages from-to

259

UT code for WoS article

000464194500002

EID of the result in the Scopus database

2-s2.0-85042859952