Regulation of microtubule nucleation mediated by gamma-tubulin complexes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00487077" target="_blank" >RIV/68378050:_____/17:00487077 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00709-016-1070-z" target="_blank" >http://dx.doi.org/10.1007/s00709-016-1070-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-016-1070-z" target="_blank" >10.1007/s00709-016-1070-z</a>

Result language

angličtina

Original language name

Regulation of microtubule nucleation mediated by gamma-tubulin complexes

Original language description

The microtubule cytoskeleton is critically important for spatio-temporal organization of eukaryotic cells. The nucleation of new microtubules is typically restricted to microtubule organizing centers (MTOCs) and requires gamma-tubulin that assembles into multisubunit complexes of various sizes. gamma-Tubulin ring complexes (TuRCs) are efficient microtubule nucleators and are associated with large number of targeting, activating and modulating proteins. gamma-Tubulin-dependent nucleation of microtubules occurs both from canonical MTOCs, such as spindle pole bodies and centrosomes, and additional sites such as Golgi apparatus, nuclear envelope, plasma membrane-associated sites, chromatin and surface of pre-existing microtubules. Despite many advances in structure of gamma-tubulin complexes and characterization of gamma TuRC interacting factors, regulatory mechanisms of microtubule nucleation are not fully understood. Here, we review recent work on the factors and regulatory mechanisms that are involved in centrosomal and non-centrosomal microtubule nucleation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/LD13015" target="_blank" >LD13015: Microtubules in activated mast cells - targets for innovative therapies</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Protoplasma

ISSN

0033-183X

e-ISSN

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Volume of the periodical

254

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

13

Pages from-to

1187-1199

UT code for WoS article

000399037400006

EID of the result in the Scopus database

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