Dysregulation of Microtubule Nucleating Proteins in Cancer Cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554549" target="_blank" >RIV/68378050:_____/21:00554549 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2072-6694/13/22/5638" target="_blank" >https://www.mdpi.com/2072-6694/13/22/5638</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers13225638" target="_blank" >10.3390/cancers13225638</a>

Result language
angličtina
Original language name
Dysregulation of Microtubule Nucleating Proteins in Cancer Cells
Original language description
Simple Summary: The dysfunction of microtubule nucleation in cancer cells changes the overall cytoskeleton organization and cellular physiology. This review focuses on the dysregulation of the gamma-tubulin ring complex (gamma-TuRC) proteins that are essential for microtubule nucleation. Recent research on the high-resolution structure of gamma-TuRC has brought new insight into the microtubule nucleation mechanism. We discuss the effect of gamma-TuRC protein overexpression on cancer cell behavior and new drugs directed to gamma-tubulin that may offer a viable alternative to microtubule-targeting agents currently used in cancer chemotherapy.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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