Domain structure of HelD, an interaction partner of Bacillus subtilis RNA polymerase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F19%3A00504953" target="_blank" >RIV/61388971:_____/19:00504953 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/19:00504953
Result on the web
<a href="https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13385" target="_blank" >https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13385</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/1873-3468.13385" target="_blank" >10.1002/1873-3468.13385</a>
Alternative languages
Result language
angličtina
Original language name
Domain structure of HelD, an interaction partner of Bacillus subtilis RNA polymerase
Original language description
The HelD is a helicase-like protein binding to Bacillus subtilis RNA polymerase (RNAP), stimulating transcription in an ATP-dependent manner. Here, our small angle X-ray scattering data bring the first insights into the HelD structure: HelD is compact in shape and undergoes a conformational change upon substrate analog binding. Furthermore, the HelD domain structure is delineated, and a partial model of HelD is presented. In addition, the unique N-terminal domain of HelD is characterized as essential for its transcription-related function but not for ATPase activity, DNA binding, or binding to RNAP. The study provides a topological basis for further studies of the role of HelD in transcription.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FEBS Letters
ISSN
0014-5793
e-ISSN
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Volume of the periodical
593
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
996-1005
UT code for WoS article
000467748900011
EID of the result in the Scopus database
2-s2.0-85064731642