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beta-glucan as a new tool in vaccine development

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00520546" target="_blank" >RIV/61388971:_____/20:00520546 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/full/10.1111/sji.12833" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/sji.12833</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/sji.12833" target="_blank" >10.1111/sji.12833</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    beta-glucan as a new tool in vaccine development

  • Original language description

    Vaccination constitutes one of the major breakthroughs in human medicine. At the same time, development of more immunogenic vaccine alternatives to using aluminium-based adjuvants is one of the most important phases of vaccination development. Among different sources of carbohydrate polymers, including plants, microbes and synthetic sources tested, glucans were found to be the most promising vaccine adjuvant, as they alone stimulate various immune reactions including antibody production without any negative side effects. The use of glucan particles as a delivery system is a viable option based on the documented efficient antigen loading and receptor-targeted uptake in antigen-presenting cells. In addition to particles, soluble glucans can be used as novel hydrogels or as direct immunocyte-targeting delivery systems employing novel complexes with oligodeoxynucleotides. This review focuses on recent advances in glucan-based vaccine development from glucan-based conjugates to a glucan-based delivery and adjuvant platform.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10606 - Microbiology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    SCANDINAVIAN JOURNAL OF IMMUNOLOGY

  • ISSN

    1365-3083

  • e-ISSN

  • Volume of the periodical

    91

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    e12833

  • UT code for WoS article

    000496121300001

  • EID of the result in the Scopus database

    2-s2.0-85075024264