The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00531162" target="_blank" >RIV/61388971:_____/20:00531162 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275" target="_blank" >https://journals.plos.org/plosgenetics/article?rev=1&id=10.1371/journal.pgen.1008275</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pgen.1008275" target="_blank" >10.1371/journal.pgen.1008275</a>
Alternative languages
Result language
angličtina
Original language name
The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis
Original language description
We observed that the second messenger (p)ppGpp, known to be synthesized by the ribosome-associated Rel synthetase upon nutrient starvation during the stringent response, is also intricately involved in the stress response of B. subtilis cells and can act as a pleiotropic regulator during the adaptation to heat stress. (p)ppGpp can slow down and modulate translation and is, together with the transcriptional stress regulator Spx, partially involved in the transcriptional down-regulation of the translation machinery. The stress-induced elevation of cellular (p)ppGpp levels confers increased stress tolerance and facilitates an improved protein homeostasis by modulating translation and reducing the load on the protein quality control system.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS Genetics
ISSN
1553-7404
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
34
Pages from-to
e1008275
UT code for WoS article
000524758200046
EID of the result in the Scopus database
2-s2.0-85082542735