Cytoprotective Activity of Natural and Synthetic Antioxidants

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F20%3A00537777" target="_blank" >RIV/61388971:_____/20:00537777 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2076-3921/9/8/713/htm" target="_blank" >https://www.mdpi.com/2076-3921/9/8/713/htm</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Cytoprotective Activity of Natural and Synthetic Antioxidants
Original language description
Numerous chronic diseases including cancer, cardiovascular, chronic respiratory or neurodegenerative diseases, diabetes mellitus, retinal damage, and others are associated with oxidative stress. Therefore, various natural and synthetic antioxidants are proposed for the prevention and treatment of such diseases . Cellular protection against oxidative and electrophile toxicitiesn(chemoprevention) can be provided either by redox-active, short-living direct antioxidants or indirect antioxidants having both anti- and prooxidant activity, activating the Keap1/Nrf2/ARE pathway, which results in the transcriptional induction of cytoprotective proteins . Individual antioxidant protective systems in humans cooperate in a complex functional interplay, cytoprotective proteins are involved in the synthesis and/or regeneration of direct antioxidants, which in turn are often required for the catalytic functions of cytoprotective proteins, which are the real ´antioxidant´ effectors . Direct antioxidant therapy often failed in clinical trials and recent studies mostly confirm the involvement of several cell signaling pathways in cytoprotection from oxidative stress.
Czech name
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Czech description
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Project
<a href="/en/project/LTC18003" target="_blank" >LTC18003: Personalized Nutrition in aging society: redox control of major age-related dise-ases (NutRedOx)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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