Growth suppression of bacteria by biofilm deterioration using silver nanoparticles with magnetic doping

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F22%3A00565981" target="_blank" >RIV/61388971:_____/22:00565981 - isvavai.cz</a>

Alternative codes found

RIV/46747885:24220/22:00010035 RIV/46747885:24620/22:00010035

Result on the web

<a href="https://pubs.rsc.org/en/content/articlelanding/2022/NR/D2NR03902H" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2022/NR/D2NR03902H</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d2nr03902h" target="_blank" >10.1039/d2nr03902h</a>

Result language

angličtina

Original language name

Growth suppression of bacteria by biofilm deterioration using silver nanoparticles with magnetic doping

Original language description

Decades of antibiotic use and misuse have generated selective pressure toward the rise of antibiotic-resistant bacteria, which now contaminate our environment and pose a major threat to humanity. According to the evolutionary ´Red queen theory´, developing new antimicrobial technologies is both urgent and mandatory. While new antibiotics and antibacterial technologies have been developed, most fail to penetrate the biofilm that protects bacteria against external antimicrobial attacks. Hence, new antimicrobial formulations should combine toxicity for bacteria, biofilm permeation ability, biofilm deterioration capability, and tolerability by the organism without renouncing compatibility with a sustainable, low-cost, and scalable production route as well as an acceptable ecological impact after the ineluctable release of the antibacterial compound in the environment. Here, we report on the use of silver nanoparticles (NPs) doped with magnetic elements (Co and Fe) that allow standard silver antibacterial agents to perforate bacterial biofilms through magnetophoretic migration upon the application of an external magnetic field. The method has been proved to be effective in opening micrometric channels and reducing the thicknesses of models of biofilms containing bacteria such as Enterococcus faecalis, Enterobacter cloacae, and Bacillus subtilis. Besides, the NPs increase the membrane lipid peroxidation biomarkers through the formation of reactive oxygen species in E. faecalis, E. cloacae, B. subtilis, and Pseudomonas putida colonies. The NPs are produced using a one-step, scalable, and environmentally low-cost procedure based on laser ablation in a liquid, allowing easy transfer to real-world applications. The antibacterial effectiveness of these magnetic silver NPs may be further optimized by engineering the external magnetic fields and surface conjugation with specific functionalities for biofilm disruption or bactericidal effectiveness.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10606 - Microbiology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Nanoscale

ISSN

2040-3364

e-ISSN

2040-3372

Volume of the periodical

14

Issue of the periodical within the volume

48

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

18143-18156

UT code for WoS article

000892544200001

EID of the result in the Scopus database

2-s2.0-85144023669