Quantification of interaction frequency between antigenpresenting cells and T cells by conjugation assay

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F23%3A00572809" target="_blank" >RIV/61388971:_____/23:00572809 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S0091679X22001066?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0091679X22001066?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.mcb.2022.07.015" target="_blank" >10.1016/bs.mcb.2022.07.015</a>

Result language
angličtina
Original language name
Quantification of interaction frequency between antigenpresenting cells and T cells by conjugation assay
Original language description
Interaction between an antigen-presenting cell and a T cell, and their subsequent conjugation are a prerequisite for the formation of the immunological synapse and productive, antigen-dependent activation of T cells. This initial interaction is accompanied by recognition of the presented antigen by the T cell receptor, and by changes in the morphology of the interacting cells and in actin cytoskeleton structure in the site of interaction. The experimental protocol below describes a simple assay for quantitative assessment of antigen-presenting cells-T cell conjugation using confocal microscopy or flow cytometry.
Czech name
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Czech description
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Project
<a href="/en/project/GA22-05356S" target="_blank" >GA22-05356S: Hierarchy of expression and translocation of effectors by intracellular Salmonella</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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