Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00601919" target="_blank" >RIV/61388971:_____/24:00601919 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/24:00601919 RIV/00216208:11130/24:10487365 RIV/00216208:11310/24:10487365 RIV/00064203:_____/24:10487365

Result on the web

<a href="https://www.tandfonline.com/doi/full/10.1080/1547691X.2024.2416988" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/1547691X.2024.2416988</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/1547691X.2024.2416988" target="_blank" >10.1080/1547691X.2024.2416988</a>

Result language

angličtina

Original language name

Immunogenic properties of nickel-doped maghemite nanoparticles and the implication for cancer immunotherapy

Original language description

Nanoparticles are commonly used in diagnostics and therapy. They are also increasingly being implemented in cancer immunotherapy because of their ability to deliver drugs and modulate the immune system. However, the effect of nanoparticles on immune cells involved in the anti-tumor immune response is not well understood. The study reported here showed that nickel-doped maghemite nanoparticles (FN NP) are differentially cytotoxic to cultured mouse and human cancer cell lines, causing their death without negatively impacting the subsequent anticancer immune response. It also found that FN NP induced cell death in the mouse colorectal cancer cell line CT26 and human prostate cancer cell line PC-3, but not in the human prostate cancer cell line LNCaP. The induced cancer cell death did not affect the phenotype and responsivity of the isolated mouse peritoneal macrophages, or ex vivo-generated mouse bone marrow-derived, or human monocyte-derived dendritic cells. Additionally, the induced cancer cell death did not prevent the ex vivo-generated mouse or human dendritic cells from stimulating lymphocytes and enriching cell cultures with cancer cell-reactive T-cells. In conclusion, this study shows that FN NP could be a valuable platform for targeting cancer cells without causing immunosuppressive effects on the subsequent anticancer immune response.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30102 - Immunology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunotoxicology

ISSN

1547-691X

e-ISSN

1547-6901

Volume of the periodical

21

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

2416988

UT code for WoS article

001345870400001

EID of the result in the Scopus database

2-s2.0-85208291415