Intestinal tissue levels of anti-TNF alpha, antibodies, and cytokines in paediatric Crohn disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00603798" target="_blank" >RIV/61388971:_____/25:00603798 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10489816 RIV/00064203:_____/25:10489816
Result on the web
<a href="https://www.nature.com/articles/s41598-024-83858-7" target="_blank" >https://www.nature.com/articles/s41598-024-83858-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-83858-7" target="_blank" >10.1038/s41598-024-83858-7</a>
Alternative languages
Result language
angličtina
Original language name
Intestinal tissue levels of anti-TNF alpha, antibodies, and cytokines in paediatric Crohn disease
Original language description
The aim was to explore factors associated with intestinal tissue levels of anti-TNF alpha (anti-TNF), anti-TNF antibodies, and cytokines in pediatric patients with Crohn Disease (CD). In a prospective exploratory study of CD patients undergoing ileocecal resection or colonoscopy between 6/2020 and 1/2023, we analysed tissue levels of anti-TNF, anti-TNF antibodies, and cytokines (TNF-α, IL-17, IL-1β, IFN-γ) from intestinal biopsies. Mixed-effects regression models, adjusted for potential confounders,nwere used. Data from 27 CD patients (18 females, 66.7%) were analysed. Fourteen (52%) received adalimumab (ADA) and thirteen received infliximab (IFX), with a median therapy duration of 17 (IQR 4.5–41.5) months. Higher levels of free anti-TNF were found in macroscopically inflamed tissue compared to non-inflamed tissue (β=3.42, 95% CI 1.05–6.10). No significant association was found between serum and tissue anti-TNF levels (β= −0.06, 95% CI −0.70–0.58). Patients treated longernwith anti-TNF had increased IL-17 levels (β=0.19, 95% CI 0.05–0.33), independent of disease duration and age. IFN-γ levels were linked with both follow-up duration and anti-TNF length. Our study shows significantly higher free drug levels in inflamed tissue. Long-term anti-TNF treatment has been linked to increased IL-17 levels, suggesting a possible impact on the cytokine response pathway. We did not observe a relationship between serum and tissue anti-TNF levels.
Czech name
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Czech description
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Classification
Type
J<sub>ost</sub> - Miscellaneous article in a specialist periodical
CEP classification
—
OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/EH22_008%2F0004597" target="_blank" >EH22_008/0004597: Talking microbes - understanding microbial interactions within One Health framework</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1138
UT code for WoS article
001393111000023
EID of the result in the Scopus database
2-s2.0-85214207190