Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F05%3A00029921" target="_blank" >RIV/61388980:_____/05:00029921 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates
Original language description
Thymidine conjugates containing metallacarborane, {8-[5-(N-3-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (5) and {8-[5-(O-4-thymidine)-3-oxa-pentoxy]-3-cobalt bis(1,2-dicarbollide)}(-) (6) ions and several simple [3-cobalt bis(1,2-dicarbollide)]- ion (1) derivatives have been studied as potential boron carriers for BNCT. Compound 6 and some nonnucleoside derivatives of 1 were not toxic above 100 mu M. The partition coefficient for both metallacarborane bearing thymidine conjugates 5 and6 was more than 500 times higher than that of unmodified nucleoside. The cellular uptake studies showed accumulation of compounds 6 in V79 Chinese hamster cells but not of compound 5. The low toxicity of conjugate type of 6 together with its high partition coefficient suggest that judicially designed derivatives of metallacarboranes can be considered as potential boron carriers for BNCT.
Czech name
K novým bórovým nosičům pro bor- neutron záchytovou terapii: metallakarborany a jejich nukleosidové konjugáty
Czech description
K novým bórovým nosičům pro bor- neutron záchytovou terapii: metallakarborany a jejich nukleosidové konjugáty.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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