The Coumarin-Based Silver(I) Complex Showed Enhanced Antitumor and Antimicrobial Activity than Ligand Itself
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F25%3A00636024" target="_blank" >RIV/61388980:_____/25:00636024 - isvavai.cz</a>
Result on the web
<a href="https://hdl.handle.net/11104/0367025" target="_blank" >https://hdl.handle.net/11104/0367025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/inorganics13050164" target="_blank" >10.3390/inorganics13050164</a>
Alternative languages
Result language
angličtina
Original language name
The Coumarin-Based Silver(I) Complex Showed Enhanced Antitumor and Antimicrobial Activity than Ligand Itself
Original language description
In this study, a novel silver(I) complex [Ag(HL1)2]NO3 (AgHL1) with coumarin derivative (3E)-3-(1-{[(pyridin-2-yl)methyl]amino}ethylidene)-3,4-dihydro-2H-benzopyran-2,4-dione (HL1) was prepared. The compounds HL1 and AgHL1 were characterized by IR and NMR spectroscopy, elemental analysis, and single crystal X-ray structural analysis. Specifically, the single crystal X-ray analysis determined the structures of both compounds HL1 and AgHL1 in their solid state, while NMR spectroscopy was used for structural determination in a solution. The HL1 proved to be a monodentate ligand and is coordinated to the Ag(I) atom through a nitrogen atom from the 2-picolylamine fragment. In the complex AgHL1, two molecules of neutral HL1 are coordinated forming a nearly linear N-Ag-N arrangement. An uncoordinated nitrate anion balances the positive charge of the complex cation. NMR spectroscopy also confirmed the stability of AgHL1 in DMSO-d6 for 3 days. In vitro cytotoxicity of HL1 and AgHL1 was performed over two cancerous cell lines A549 and HT-29 and their selectivity was verified on a healthy CCD-18Co cell line. AgHL1 exhibited low anticancer nonselective activity while the ligand was inactive. Also, the complex shows better antimicrobial activity than the positive controls on the Pseudomonas aeruginosa standard and clinical strain as well as on the tested molds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Inorganic
ISSN
2304-6740
e-ISSN
2304-6740
Volume of the periodical
13
Issue of the periodical within the volume
5
Country of publishing house
CH - SWITZERLAND
Number of pages
21
Pages from-to
164
UT code for WoS article
001496461900001
EID of the result in the Scopus database
2-s2.0-105006554066