Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388998%3A_____%2F14%3A00431713" target="_blank" >RIV/61388998:_____/14:00431713 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26220/14:PU111652 RIV/00216224:14110/14:00080144

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Dual effect of ethanol on inward rectifier potassium current IK1 in rat ventricular myocytes

Original language description

Alcohol consumption may result in electrocardiographic changes and arrhythmias. Important role of modifications of the inward rectifier potassium current IK1 in arrhythmogenesis is well established. Considering lack of relevant data, we aimed at studyingthe effect of 0.2?200 mM ethanol on IK1 in enzymatically isolated rat right ventricular myocytes using the whole cell patch-clamp technique at 231°C. Ethanol reversibly affected IK1 in a dual way. At a very low concentration of 0.8 mM (0.004%), ethanolsignificantly decreased IK1 by 6.92.7%. However, at concentrations of ethanol higher than 8 mM (0.04%), IK1 was conversely significantly increased (by 16.64.0% at 20 mM and 24.52.4% at 80 mM). The steady-state IK1 increase was regularly preceded by its transient decrease at the beginning of ethanol application. Under 2 and 8 mM ethanol, IK1 was decreased at the steady-state in some cells but increased in others. Both effects were voltage-independent. In agreement with the observed effect

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BO - Biophysics

OECD FORD branch

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Project

<a href="/en/project/NT14301" target="_blank" >NT14301: Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents: a link to atrial fibrillation related to alcohol consumption?</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physiology and Pharmacology

ISSN

0867-5910

e-ISSN

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Volume of the periodical

65

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

13

Pages from-to

497-509

UT code for WoS article

000343017300005

EID of the result in the Scopus database

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