Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389005%3A_____%2F08%3A00311340" target="_blank" >RIV/61389005:_____/08:00311340 - isvavai.cz</a>
Alternative codes found
RIV/61389005:_____/08:00320930 RIV/68378050:_____/08:00320930
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Radioiodination of mouse anti-III beta-tubulin antibodies and their evaluation with respect to their use as diagnostic agents for peripheral neuropathies
Original language description
The monoclonal antibody TU-20 and its scFv fragment were radiolabeled with (125)I in order to develop new imaging agents against the specific neuronal marker III beta-tubulin. The reaction via chloramine-T using thiosulfate as a stopping reductant was determined as the most convenient way for radioiodination. The preserved immunological properties of radioiodinated species were estimated by ELISA, electrophoresis, and immunohistochemistry with autoradiography. Biodistribution studies revealed a different behavior of radioiodinated TU-20 and its scFv.
Czech name
Radiojodizace myších anti-III beta-tubulinových protilátek a jejich vyhodnocení vzhledem k jejich užití jako diagnostických prostředků pro periferální neuropatie
Czech description
Monoklonální protilátka TU-20 a její scFv fragment byly radioaktivně značeny (125)I s cílem vyvinout nový zobrazovcí prostředek k specifickému neuronálnímu značkovači III beta-tubulinu.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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